God did not call us to be impure, but to live a holy life. Therefore, anyone who rejects this instruction does not reject a human being but God, the very God who gives you His Holy Spirit (1 Thess. 4:7-8).
God's purpose for us is holiness–to be sanctified or set apart for Him and His use.
Rejecting God's purpose for us as it is revealed in His Word is to reject Him personally.
The KJV uses the word "despise," literally "un-place Him." "Despise" is not a word I hear often. It's an intense, deep hatred of something or someone, and it's usually reserved for the times that we are so averse to something that we can't stand the thought of it.
Yet the Bible will use the word interchangeably with "reject" and "contempt."
"'If I am a master, where is the respect due Me?' says the LORD Almighty. 'It is you priests who show contempt for My Name'" (Mal. 1:6).
David was guilty of the same thing as Nathan indicted him: "Why have you despised the word of the LORD, to do what is evil in his sight?" (2 Sam. 12:9)
Knowing how the Bible qualifies people who reject the Word of God, does this change our perspective? Many have made the mistake of failing to take the Bible seriously.
Human tendency is to view the indifferent or agnostic as being in a "gray area," harmlessly vacillating at best, but not outright hostile. But this is not how the Bible presents people: "There is no one righteous, not even one" (Rom. 3:10).
To live apart from God's purpose is to be hostile toward Him (Col. 1:21). To remain separated from Him–unforgiven–to be His enemy (Rom. 5:10).
His Truth, the sacrifice of His Son, and the grace He offers are not superfluous propositions extended to "enhance" your already sterling record.
Jesus Christ did not come and die on a cross to make "good" people better. He came to save us from our sins, and from the wrath our sin incurs (1 Tim. 2:4).
Anyone who refuses Him (however graciously) remains under God's wrath (Rom. 5:9; 1 Thess. 1:10). God did not call us to be impure, but to live a holy life. All things are possible with God, including this. He made living a holy possible through the forgiveness found in His Son.
The question for you and me is, "What must I do to be saved?"
"When the people heard this, they were cut to the heart and asked Peter and the other apostles, “Brothers, what shall we do?” Peter replied, “Repent and be baptized, every one of you, in the name of Jesus Christ for the forgiveness of your sins..." (Acts 2:37-38).
...if we walk in the Light as He Himself is in the Light, we have fellowship with one another, and the blood of Jesus His Son cleanses us from all sin (1 Jn. 1:7).